Patients with cancer face a significant risk of cardiovascular death, regardless of time since cancer diagnosis. Elderly patients are particularly more susceptible as cancer-associated cardiac complications present in advanced stage cancer. These patients may often present with symptoms observed in chronic heart failure (HF). Cardiac wasting, commonly observed in these patients, is a multifaceted syndrome characterized by systemic metabolic alterations and inflammatory processes that specifically affect cardiac function and structure. Experimental and clinical studies have demonstrated that cancer-associated cardiac wasting is linked with cardiac atrophy and altered cardiac morphology, which impairs cardiac function, particularly pertaining to the left ventricle. Therefore, this review aims to present a summary of epidemiologic data and pathophysiological mechanisms of cardiac wasting due to cancer, and future directions in this field.

无论癌症诊断后的时间如何，癌症患者都面临着心血管死亡的重大风险。老年患者尤其容易受到晚期癌症中癌症相关心脏并发症的影响。这些患者通常可能出现慢性心力衰竭 (HF) 的症状。在这些患者中常见的心脏衰竭是一种多方面的综合征，其特征是全身代谢改变和炎症过程，特别影响心脏功能和结构。实验和临床研究表明，癌症相关的心脏衰竭与心脏萎缩和心脏形态改变有关，这会损害心脏功能，特别是左心室的功能。因此，本综述旨在总结癌症引起的心脏衰竭的流行病学数据和病理生理机制，以及该领域的未来方向。