The invasion of viruses and fungi can cause pathological changes in the normal growth of plants and is an important factor in causing plant infectious diseases. These pathogenic microorganisms can also secrete toxic metabolites, affecting crop quality and posing a threat to human health. In this work, we selected the natural product rutaecarpine as the lead compound to achieve the total synthesis and structural derivation. The antiphytoviral activities of these compounds were systematically studied using tobacco mosaic virus (TMV) as the tested strain, and the structure–activity relationships were summarized.

中文翻译：

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从自然界中发现新的候选农药：芸香碱衍生物的设计、合成和生物活性研究


病毒和真菌的入侵会引起植物正常生长的病理变化，是引起植物传染病的重要因素。这些病原微生物还可以分泌有毒代谢物，影响作物品质，对人体健康构成威胁。在这项工作中，我们选择了天然产物芸香碱作为主要化合物，以实现总合成和结构衍生。以烟草花叶病毒 （TMV） 为供试菌株，系统研究这些化合物的抗植物病毒活性，并总结其构效关系。