The development of economically viable and environmentally neutral tools to control insects that consume or damage over 20% of global agriculture or vector human and animal disease represents one of the most important challenges of the 21st century. The suite of chemical-based strategies currently employed to control insect populations rely primarily on insecticides, which are subject to rapid resistance and often have harmful off-target environmental and health-related impacts, and, to a lesser degree, repellents, which typically rely on masking attractive odors. The discovery and characterization of Vanderbilt University allosteric agonists (VUAAs), a family of small-molecule agonists that target the highly conserved, insect-specific odorant receptor coreceptor (Orco), raise the potential for the development of a novel repellent paradigm for vector/pest management. VUAAs have the potential to target nearly all insect olfactory sensory neurons, leading to highly aversive behavioral responses, but importantly have limited volatility, thereby reducing their utility as spatial repellents.

中文翻译：

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范德堡大学变构激动剂热解成分的二元混合物可作为疟疾病媒蚊子的挥发性空间驱虫剂


开发经济上可行且环境中和的工具来控制消耗或破坏全球 20% 以上农业的昆虫或传播人类和动物疾病，这是 21 世纪最重要的挑战之一。目前用于控制昆虫种群的化学策略主要依赖于杀虫剂，杀虫剂会迅速产生耐药性，并且通常会对环境和健康产生有害的脱靶影响，在较小程度上，驱虫剂通常依赖于掩盖诱人的气味。范德堡大学变构激动剂 （VUAA） 的发现和表征是针对高度保守的昆虫特异性气味受体辅助受体 （Orco） 的小分子激动剂家族，提高了开发用于媒介/害虫管理的新型驱虫范式的潜力。VUAA 有可能靶向几乎所有昆虫的嗅觉感觉神经元，导致高度厌恶的行为反应，但重要的是，它们的波动性有限，从而降低了它们作为空间驱避剂的效用。