Carborane has been extensively researched and used in the anti-tumor sector because of its high boron content and remarkable chemical stability. Its limited water solubility, however, stems from the fact that it is a fat-soluble molecule. In this paper, firstly, the water-soluble nido-carborane potassium salt was prepared by the nucleophilic deboronation of closo-o-carborane, then rhodamine B is introduced as a fluorescent marker, and finally, four acrylic resins with different characteristics are coated to obtain L100-Rho-B, EPO-Rho-B, RL-Rho-B, and RS-Rho-B. Four kinds of borane compounds were characterized. The wavelength range of the fluorescence emission varied between 568 and 579 nm in several organic solvents. The chemicals were seen to be dispersed in long strips or stacked in sheets using transmission electron microscopy. A simulated in vitro release test demonstrated that the resin’s characteristics affected the composite’s release. The release performance of L100-Rho-B and EPO-Rho-B was superior to RL-Rho-B and RS-Rho-B, and there was a higher cumulative release amount at pH 6.5. To observe the biocompatibility of compounds with tumor cells, live cell imaging studies were conducted, and it was found that L100-Rho-B and EPO-Rho-B all have good biocompatibility.

Graphical abstract

pH-responsive acrylic resin complexe

中文翻译：

---

pH 响应型丙烯酸树脂，用于罗丹明-尼多-碳硼烷荧光复合物的缓释和细胞成像

碳硼烷因其高硼含量和卓越的化学稳定性而在抗肿瘤领域得到广泛研究和应用。然而，它的水溶性有限源于它是脂溶性分子。本文首先通过邻碳硼烷的亲核脱硼反应制备了水溶性的尼多碳硼烷钾盐，然后引入罗丹明B作为荧光标记物，最后将四种不同特性的丙烯酸树脂涂覆在获得L100-Rho-B 、 EPO-Rho-B 、 RL-Rho-B和RS-Rho-B 。对四种硼烷化合物进行了表征。在几种有机溶剂中，荧光发射的波长范围在 568 至 579 nm 之间变化。使用透射电子显微镜观察发现，这些化学物质分散成长条状或堆叠成片状。模拟体外释放测试表明，树脂的特性影响复合材料的释放。 L100-Rho-B和EPO-Rho-B的释放性能优于RL-Rho-B和RS-Rho-B ，并且在pH 6.5时有较高的累积释放量。为了观察化合物与肿瘤细胞的生物相容性，进行了活细胞成像研究，发现L100-Rho-B和EPO-Rho-B均具有良好的生物相容性。

 图文摘要

pH 响应型丙烯酸树脂复合物