The Himalayan plant Inula racemosa has medicinal properties and can be used to prevent or treat cancer. This is because it contains certain chemicals that are known to fight cancer cells with few or no side effects. I. racemosa has been used for this purpose for many years in traditional medicine and has shown promising results. The present study was crafted to explore the suppressive impacts on cellular proliferation of the root extract derived from I. racemosa via in vivo experimentation. I. racemosa (IR) root extract was tested at three different doses (100, 250, and 500 mg/Kg BW) for 18 weeks to assess its anti‐neoplastic activity against mammary tumors in female rats. The assessment included various parameters such as hematological and biochemical indices, tumor parameters, oxidative stress analysis, gross and histopathological lesion determination, Masson's trichrome staining, immunohistochemical expression of Ki‐67, MMP‐9, and VEGF in mammary gland tissues, and molecular docking. The chemopreventive action of IR root extract was demonstrated by the inhibition of tumor parameters (tumor size and tumor volume), minimum changes in the liver (ALT, AST, and ALP) and kidney enzymes (BUN and creatinine), declined lipid peroxidation activity, decline gross, and histological changes in mammary gland tumors, reduced expression of KI‐67, MMP‐9, and VEGF and maximum binding affinity of isoalantolactone with VEGF through molecular docking. The study suggests that the active constituents (isoalantolactone and alantolactone) of I. racemosa roots have anti‐neoplastic activity against mammary tumors, making them a valuable therapeutic regimen for the future.

中文翻译：

---

揭示 Inula racemosa Hook 的抗癌潜力。f. 根提取物对抗 Sprague Dawley 大鼠 DMBA 诱导的乳腺肿瘤


喜马拉雅植物 Inula racemosa 具有药用价值，可用于预防或治疗癌症。这是因为它含有某些已知可以对抗癌细胞的化学物质，副作用很少或没有。I. racemosa 在传统医学中已为此目的使用多年，并显示出可喜的结果。本研究旨在通过体内实验探索总状花藻根提取物对细胞增殖的抑制影响。总状鸢尾螨 （IR） 根提取物以三种不同剂量 （100、250 和 500 mg/Kg BW） 进行了 18 周的测试，以评估其对雌性大鼠乳腺肿瘤的抗肿瘤活性。评估包括各种参数，例如血液学和生化指标、肿瘤参数、氧化应激分析、大体和组织病理学病变测定、Masson 三色染色、乳腺组织中 Ki-67、MMP-9 和 VEGF 的免疫组织化学表达，以及分子对接。IR 根提取物的化学预防作用表现为抑制肿瘤参数 （肿瘤大小和肿瘤体积）、肝脏 （ALT、AST 和 ALP） 和肾酶 （BUN 和肌酐） 的最小变化，乳腺肿瘤脂质过氧化活性下降、总体和组织学变化下降，KI-67 、 MMP-9 和 VEGF 的表达降低以及异戊内酯与VEGF 的最大结合亲和力通过分子对接。研究表明，总状鸢尾菌根的活性成分（异内酯和丙内酯）对乳腺肿瘤具有抗肿瘤活性，使其成为未来有价值的治疗方案。