As part of the response to the highly pathogenic avian influenza A(H5N1) virus outbreak in U.S. cattle and poultry and the associated human cases, CDC and partners are monitoring influenza A virus levels and detection of the H5 subtype in wastewater. Among 48 states and the District of Columbia that performed influenza A testing of wastewater during May 12-July 13, 2024, a weekly average of 309 sites in 38 states had sufficient data for analysis, and 11 sites in four states reported high levels of influenza A virus. H5 subtype testing was conducted at 203 sites in 41 states, with H5 detections at 24 sites in nine states. For each detection or high level, CDC and state and local health departments evaluated data from other influenza surveillance systems and partnered with wastewater utilities and agriculture departments to investigate potential sources. Among the four states with high influenza A virus levels detected in wastewater, three states had corresponding evidence of human influenza activity from other influenza surveillance systems. Among the 24 sites with H5 detections, 15 identified animal sources within the sewershed or adjacent county, including eight milk-processing inputs. Data from these early investigations can help health officials optimize the use of wastewater surveillance during the upcoming respiratory illness season.

中文翻译：

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与牛、家禽和相关人类病例中高致病性甲型禽流感 (H5N1) 病毒爆发同时发生的甲型流感病毒和 H5 亚型废水监测 - 美国，2024 年 5 月 12 日至 7 月 13 日。


作为应对美国牛和家禽中高致病性禽流感 A(H5N1) 病毒爆发以及相关人类病例的一部分，CDC 及其合作伙伴正在监测废水中的甲型流感病毒水平并检测 H5 亚型。在2024年5月12日至7月13日期间对废水进行甲型流感检测的48个州和哥伦比亚特区中，每周平均有38个州的309个站点有足够的数据进行分析，其中4个州的11个站点报告了高水平的流感一种病毒。 H5 亚型测试在 41 个州的 203 个地点进行，其中 H5 检测在 9 个州的 24 个地点进行。对于每次检测或高水平，疾病预防控制中心以及州和地方卫生部门都会评估来自其他流感监测系统的数据，并与废水处理设施和农业部门合作调查潜在来源。在废水中检测到甲型流感病毒水平较高的四个州中，三个州从其他流感监测系统中获得了人类流感活动的相应证据。在检测到 H5 的 24 个地点中，有 15 个地点在下水道或邻近县内确定了动物来源，其中包括 8 个牛奶加工投入品。这些早期调查的数据可以帮助卫生官员在即将到来的呼吸道疾病季节优化废水监测的使用。