Phenazine natural products are a class of nitrogen-containing heterocyclic compounds produced by microorganisms. The tricyclic ring molecules show various chemical structures and extensive pharmacological activities, such as antimicrobial, anticancer, antiparasitic, anti-inflammatory, and insecticidal activities, with low toxicity to the environment. Since phenazine-1-carboxylic acid has been developed as a registered biopesticide, the application of phenazine natural products will be promising in the field of agriculture pathogenic fungi control based on broad-spectrum antifungal activity, minimal toxicity to the environment, and improvement of crop production. Currently, there are still plenty of intriguing hidden biosynthetic pathways of phenazine natural products to be discovered, and the titer of naturally occurring phenazine natural products is insufficient for agricultural applications. In this review, we spotlight the progress regarding biosynthesis and metabolic engineering research of phenazine natural products in the past decade. The review provides useful insights concerning phenazine natural products production and more clues on new phenazine derivatives biosynthesis.

中文翻译：

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吩嗪天然产物的最新进展：生物合成和代谢工程


吩嗪天然产物是一类由微生物产生的含氮杂环化合物。三环分子具有多种化学结构和广泛的药理活性，如抗菌、抗癌、抗寄生虫、抗炎、杀虫活性，且对环境毒性低。由于吩嗪-1-甲酸已被开发为注册生物农药，吩嗪天然产物因其广谱抗真菌活性、对环境的毒性小、改良作物等特点，在农业病原真菌防治领域具有广阔的应用前景。生产。目前，仍有大量令人感兴趣的吩嗪天然产物隐藏的生物合成途径有待发现，并且天然存在的吩嗪天然产物的效价不足以用于农业应用。在这篇综述中，我们重点介绍了过去十年吩嗪天然产物生物合成和代谢工程研究的进展。该综述提供了有关吩嗪天然产物生产的有用见解以及有关新吩嗪衍生物生物合成的更多线索。