Intracellularly manipulable aggregation of the aggregation-induced emission luminogens,Biosensors and Bioelectronics

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Intracellularly manipulable aggregation of the aggregation-induced emission luminogens
Biosensors and Bioelectronics ( IF 10.7 ) Pub Date : 2024-09-19 , DOI: 10.1016/j.bios.2024.116800
Wen-Jin Wang ₁ , Zhuo-Yang Xin ₁ , Dan Liu ₁ , Qian Liu ₂ , Yong Liu ₃ , Zijie Qiu ₁ , Jianquan Zhang ₁ , Parvej Alam ₁ , Xu-Min Cai ₄ , Zheng Zhao ₁ , Ben Zhong Tang ₅

Affiliation

Biophotonics has seen significant advancements with the development of optical imaging techniques facilitating the noninvasive detection of biologically relevant species. Aggregation-induced emission (AIE) materials have emerged as a novel class of luminogens exhibiting enhanced luminescence or photodynamic efficiency in the aggregated state, making them ideal for biomedical applications. The intracellularly controlled aggregation of aggregate-induced emission luminogens (AIEgens) enables high-resolution imaging of intracellular targets and diagnosis of related diseases, and enables disease therapy by exploiting the novel properties of aggregates. This review provides an in-depth analysis of the strategies employed to modulate the aggregation of AIEgens, focusing on the importance of molecular modifications to improve hydrophilicity and achieve precise control over the intercellular aggregation of AIEgens. Furthermore, the representative applications of AIEgens in bioimaging, such as enzyme activity monitoring, protein tracking, organelle function monitoring, and in vivo tumor-specific therapeutics, are reviewed. Additionally, we outline the challenges and future opportunities for AIE research, emphasizing the importance of the strategies for realizing the precisely controllable aggregation of AIEgens inside cells and the need for extending AIEgens’ absorption and emission wavelengths. This review aims to elucidate the rational development of responsive AIEgens for advanced biomedical applications.

中文翻译：

聚集诱导的发光源的细胞内可操纵聚集

随着光学成像技术的发展，生物光子学取得了重大进步，促进了生物相关物种的无创检测。聚集诱导发射（AIE）材料已成为一类新型发光剂，在聚集状态下表现出增强的发光或光动力效率，使其成为生物医学应用的理想选择。聚集体诱导发射发光体（AIEgens）的细胞内受控聚集能够对细胞内靶标进行高分辨率成像和相关疾病的诊断，并通过利用聚集体的新特性实现疾病治疗。本文深入分析了用于调节 AIEgens 聚集的策略，重点关注分子修饰对提高亲水性和实现对 AIEgens 细胞间聚集的精确控制的重要性。此外，还综述了 AIEgens 在生物成像中的代表性应用，例如酶活性监测、蛋白质追踪、细胞器功能监测和体内肿瘤特异性治疗。此外，我们概述了 AIE 研究的挑战和未来机遇，强调了实现 AIEgens 在细胞内精确可控聚集的策略的重要性，以及扩展 AIEgens 吸收和发射波长的必要性。本文旨在阐明响应式 AIEgens 在高级生物医学应用中的合理发展。

更新日期：2024-09-19

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