PURPOSE Exertional heat stress can induce systemic endotoxin exposure and a pro-inflammatory cascade, likely impairing thermoregulation. Cannabidiol (CBD) is protective in pre-clinical models of tissue ischaemia and inflammation. Therefore, this study examined the effects of CBD ingestion on exercise-induced thermoregulatory and inflammatory responses. METHODS In a randomised, double-blinded study, thirteen active males (age 25 ± 5 y; peak oxygen uptake [V̇O2peak] 50.4 ± 3.2 mL/kg/min) ingested 298 mg CBD or placebo 105 minutes before 1 h treadmill exercise (60-65% V̇O2peak) in 32 °C and 50% relative humidity. Core temperature, skin temperature, heart rate, subjective outcomes and sweat loss were assessed during/after exercise. Plasma osmolality, plasma volume changes and plasma markers of intestinal damage (I-FABP), monocyte activation (CD14) and inflammatory cytokine responses (IL-6, IL-8 and TNF-α) were assessed at baseline, pre-exercise, 20- and 90-min post-exercise. RESULTS Core temperature (∆ 1.69 ± 0.48 °C [CBD] and 1.79 ± 0.53 °C [Placebo]) and I-FABP increased during exercise, with no differences between conditions (p > 0.050). Mean (95% CI) CD14 was 1776 (463 to 3090) pg/mL greater 90 min post-exercise in placebo (p = 0.049). Median (interquartile range) peak IL-6 concentration was -0.8 (-1.1, -0.3) pg/mL less in CBD (p = 0.050), whilst the between-conditions difference in IL-6 area under curve was -113 (-172, 27) pg/mL·270 min (p = 0.054). CONCLUSIONS CBD did not affect thermoregulation during exertional heat stress but appeared to elicit minor immunosuppressive effects, reducing CD14 and IL-6 responses, warranting investigation in humans under more severe heat strain and other pro-inflammatory scenarios.

中文翻译：

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摄入大麻二酚对休闲活跃男性在高温下跑步机运动的体温调节和炎症反应的影响。


目的劳累性热应激可诱发全身内毒素暴露和促炎症级联反应，可能损害体温调节。大麻二酚 (CBD) 在组织缺血和炎症的临床前模型中具有保护作用。因此，这项研究探讨了 CBD 摄入对运动引起的体温调节和炎症反应的影响。方法 在一项随机、双盲研究中，13 名活跃男性（年龄 25 ± 5 岁；峰值摄氧量 [V̇O2peak] 50.4 ± 3.2 mL/kg/min）在 1 小时跑步机运动前 105 分钟摄入 298 mg CBD 或安慰剂（60 -65% V̇O2peak) 在 32 °C 和 50% 相对湿度下。在运动期间/之后评估核心温度、皮肤温度、心率、主观结果和出汗量。在基线、运动前、20 小时评估血浆渗透压、血浆容量变化以及肠道损伤血浆标记物 (I-FABP)、单核细胞活化 (CD14) 和炎症细胞因子反应（IL-6、IL-8 和 TNF-α）。 - 以及运动后 90 分钟。结果 运动期间核心温度（Δ 1.69 ± 0.48 °C [CBD] 和 1.79 ± 0.53 °C [安慰剂]）和 I-FABP 升高，但条件之间没有差异（p > 0.050）。安慰剂组运动后 90 分钟的平均 (95% CI) CD14 为 1776 (463 至 3090) pg/mL (p = 0.049)。 CBD 中 IL-6 峰值浓度的中位数（四分位距）为 -0.8 (-1.1, -0.3) pg/mL (p = 0.050)，而 IL-6 曲线下面积的条件间差异为 -113 (- 172, 27) pg/mL·270 分钟 (p = 0.054)。结论 CBD 不会影响劳累性热应激期间的体温调节，但似乎会引起轻微的免疫抑制作用，降低 CD14 和 IL-6 反应，值得在更严重的热应激和其他促炎症情况下对人类进行研究。