In this issue of Neuron, Li, Zhang, et al.1 find that the bile acid receptor TGR5 in the lateral hypothalamus influences neuronal dynamics underlying stress-induced depression-like behaviors. Inhibition of these neurons produces antidepressant-like effects through a circuit that includes hippocampal CA3 and dorsolateral septum, revealing a novel potential therapeutic for depression.

中文翻译：

---

从胆汁酸到忧郁症


在本期《Neuron》中，Li、Zhang 等人1 发现下丘脑外侧的胆汁酸受体 TGR5 影响压力诱发的抑郁样行为背后的神经元动态。抑制这些神经元通过包括海马 CA3 和背外侧隔膜的回路产生抗抑郁样作用，揭示了一种新的抑郁症潜在治疗方法。