Studies of the human microbiome are progressing rapidly but have largely focused on populations living in high-income countries. With increasing evidence that the microbiome contributes to the pathogenesis of diseases that affect infants, children, and adults in low- and middle-income countries (LMICs), and with profound and rapid ongoing changes occurring in our lifestyles and biosphere, understanding the origins of and developing microbiome-directed therapeutics for treating a number of global health challenges requires the development of programs for studying human microbial ecology in LMICs. Here, we discuss how the establishment of long-term human microbial observatory programs in selected LMICs could provide one timely approach.

中文翻译：

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在低收入和中等收入国家建立人类微生物观察站计划


人类微生物组的研究进展迅速，但主要集中在生活在高收入国家的人群。随着越来越多的证据表明微生物组有助于影响中低收入国家 （LMIC） 婴儿、儿童和成人的疾病的发病机制，以及我们的生活方式和生物圈正在发生深刻而迅速的变化，了解微生物组的起源并开发用于治疗许多全球健康挑战的微生物组定向疗法需要制定研究中低收入国家人类微生物生态学的计划。在这里，我们讨论了在选定的低收入和中等收入国家建立长期人类微生物观察计划如何提供一种及时的方法。