NIR-Triggered Cu2O/Cu2-xS Heterostructure as an “All-In-One” Functional Nanoplatform for Efficient Synergistic Tumor Therapy,Advanced Functional Materials

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NIR-Triggered Cu2O/Cu2-xS Heterostructure as an “All-In-One” Functional Nanoplatform for Efficient Synergistic Tumor Therapy
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2024-09-19 , DOI: 10.1002/adfm.202408125
Weihua Gao ₁ , Jie Zhang ₁ , Yi Chang ₁ , Fangli Gao ₁ , Guanglei Ma ₂ , Zhiyong Gao ₁ , Xiaobing Wang ₂ , Xinhe Liu ₁ , Xiaoming Ma ₂ , Yuming Guo ₁

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The fabrication of synergistic multifunctional anti-tumor nanoplatforms is challenging due to the urgent requirement to activate different therapeutic modalities. Although the multi-modal treatments can be achieved by carrying out the activation with different exogenous and endogenous stimulations in sequence, this tedious manner is not applicable to the ideal synergistic cancer treatment. Herein, a simple heterojunction of Cu₂O/Cu_2-xS modified with gambogic acid and hyaluronic acid (CCS@GA@HA) is ingeniously fabricated for the synergistic cancer treatment combining photothermal therapy (PTT), photocatalytic therapy (PCT), chemodynamic therapy (CDT) and potential ferroptosis just activated by the single near infrared (NIR) light irradiation. Cu₂O/Cu_2-xS heterostructure (CCS) with promoted separation and transfer efficiency of photogenerated charge carriers exhibits excellent photocatalytic performance. The intervention of gambogic acid (GA) downregulates the overexpression of heat shock protein 90 (HSP90), which make it possible to execute the mild PTT. And the CDT performance is efficiently improved by the heat generated from PTT. Specifically, CCS appears to accelerate the accumulation of lipid peroxides (LPO) and inactivate glutathione peroxidase 4 (GPX4) that directly induce ferroptosis. In brief, CCS@GA@HA exhibits prominent NIR-triggered synergistic effect involving PCT, mild PTT, enhanced CDT and ferroptosis for an effective multi-modal tumor treatment.

中文翻译：

NIR 触发的 Cu2O/Cu2-xS 异质结构作为用于高效协同肿瘤治疗的“一体化”功能纳米平台

由于迫切需要激活不同的治疗方式，协同多功能抗肿瘤纳米平台的制造具有挑战性。虽然可以通过依次使用不同的外源性和内源性刺激进行激活来实现多模式治疗，但这种繁琐的方式并不适用于理想的协同癌症治疗。在此，巧妙地制备了用藤黄酸和透明质酸（CCS@GA@HA）修饰的 Cu₂O/Cu_2-xS 的简单异质结，用于结合光热疗法（PTT）、光催化疗法（PCT）、化学动力学疗法（CDT）和仅由单一近红外（NIR）光照射激活的潜在铁死亡的协同癌症治疗。Cu₂O/Cu_2-xS 异质结构（CCS）提高了光生载流子的分离和转移效率，表现出优异的光催化性能。藤黄酸（GA）的干预下调了热休克蛋白 90 （HSP90）的过表达，这使得执行轻度 PTT 成为可能。PTT 产生的热量有效地提高了 CDT 性能。具体而言，CCS 似乎加速了脂质过氧化物（LPO）的积累并灭活直接诱导铁死亡的谷胱甘肽过氧化物酶 4 （GPX4）。简而言之，CCS@GA@HA 表现出显著的 NIR 触发协同效应，涉及 PCT、轻度 PTT、增强的 CDT 和铁死亡，是一种有效的多模式肿瘤治疗。

更新日期：2024-09-19

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