The dynamic process of membrane shaping and remodeling plays a vital role in cellular functions, with proteins and cellular membranes interacting intricately to adapt to various cellular needs and environmental cues. Ubiquitination—a posttranslational modification—was shown to be essential in regulating membrane structure and shape. It influences virtually all pathways relying on cellular membranes, such as endocytosis and autophagy by directing protein degradation, sorting, and oligomerization. Ubiquitin is mostly known as a protein modifier; however, it was reported that ubiquitin and ubiquitin-like proteins can associate directly with lipids, affecting membrane curvature and dynamics. In this review, we summarize some of the current knowledge on ubiquitin-mediated membrane remodeling in the context of endocytosis, autophagy, and ER-phagy.

膜成形和重塑的动态过程在细胞功能中起着至关重要的作用，蛋白质和细胞膜相互作用，以适应各种细胞需求和环境线索。泛素化（一种翻译后修饰）被证明对于调节膜结构和形状至关重要。它几乎影响所有依赖细胞膜的途径，例如通过指导蛋白质降解、排序和寡聚化的内吞作用和自噬。泛素通常被称为蛋白质修饰剂。然而，据报道，泛素和泛素样蛋白可以直接与脂质结合，影响膜曲率和动力学。在这篇综述中，我们总结了有关内吞作用、自噬和内质网吞噬背景下泛素介导的膜重塑的一些最新知识。