Recurrent SARS-CoV-2 spike mutations confer growth advantages to select JN.1 sublineages,Emerging Microbes & Infections

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Recurrent SARS-CoV-2 spike mutations confer growth advantages to select JN.1 sublineages
Emerging Microbes & Infections ( IF 8.4 ) Pub Date : 2024-09-16 , DOI: 10.1080/22221751.2024.2402880
Qian Wang _{1,

2} , Ian A Mellis _{1,

3} , Jerren Ho ₁ , Anthony Bowen _{1,

4} , Theresa Kowalski-Dobson ₅ , Riccardo Valdez ₆ , Phinikoula S Katsamba ₇ , Madeline Wu ₁ , Caitlin Lee ₁ , Lawrence Shapiro _{1,

7,

8} , Aubree Gordon ₅ , Yicheng Guo _{1,

4} , David D Ho _{1,

2,

4,

9} , Lihong Liu _{1,

4,

10,

11}

Affiliation

Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Pandemic Research Alliance unit at the Wu Center for Pandemic Research, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Division of Infectious Diseases, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Department of Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Department of Microbiology and Immunology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.
Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, People's Republic of China.

The recently dominant SARS-CoV-2 Omicron JN.1 has evolved into multiple sublineages, with recurrent spike mutations R346T, F456L, and T572I, some of which exhibit growth advantages, such as KP.2 an...

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