Utilizing electrons directly offers significant potential for advancing organic synthesis by facilitating novel reactivity and enhancing selectivity under mild conditions. As a result, an increasing number of organic chemists are exploring electrosynthesis. However, the efficacy of electrochemical transformations depends critically on the design of the electrochemical cell. Batch cells often suffer from limitations such as large inter-electrode distances and poor mass transfer, making flow cells a promising alternative. Implementing flow cells, however, requires a foundational understanding of microreactor technology. In this review, we briefly outline the applications of flow electrosynthesis before providing a comprehensive examination of existing flow reactor technologies. Our goal is to equip organic chemists with the insights needed to tailor their electrochemical flow cells to meet specific reactivity requirements effectively. We also highlight the application of reactor designs in scaling up electrochemical processes and integrating high-throughput experimentation and automation. These advancements not only enhance the potential of flow electrosynthesis for the synthetic community but also hold promise for both academia and industry.

中文翻译：

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增强有机合成中的电化学反应：流动化学的影响


直接利用电子通过在温和条件下促进新的反应性和增强选择性，为推进有机合成提供了巨大的潜力。因此，越来越多的有机化学家正在探索电合成。然而，电化学转化的功效在很大程度上取决于电化学池的设计。批量式流通池通常存在电极间距离大和传质差等限制，这使得流通池成为一种很有前途的替代方案。然而，实施流通池需要对微反应器技术有基本的了解。在这篇综述中，我们简要概述了流动电合成的应用，然后对现有的流动反应器技术进行了全面检查。我们的目标是为有机化学家提供定制电化学流通池所需的见解，以有效地满足特定的反应性要求。我们还重点介绍了反应器设计在放大电化学过程和集成高通量实验和自动化方面的应用。这些进步不仅增强了流动电合成在合成界的潜力，而且为学术界和工业界都带来了希望。