Results from studies investigating the association between maternal or child epilepsy, use of anticonvulsants in pregnancy, and childhood cancer are inconsistent and at times contradictory. Linking Danish national databases, we obtained epilepsy and childhood cancer diagnoses, and anticonvulsant use data. We estimated adjusted odds ratios of all or specific childhood cancers in relation to maternal or child epilepsy and anticonvulsant therapies using conditional logistic regression. Maternal epilepsy was positively associated with all childhood cancers in offspring, specifically, with acute lymphoblastic leukemia (Odds Ratio (OR) = 1.68, 95% Confidence Interval (CI) = 1.16, 2.43) and Wilms tumor (OR = 2.13, 95% CI = 0.97, 4.68). When considering maternal ever (lifetime) ingestion of anticonvulsants, a positive association was found with all cancers (OR = 1.14, 95% CI = 1.00, 1.30), and central nervous system tumors (CNS) (OR = 1.36, 95% CI = 1.04, 1.76) as well as neuroblastoma (OR = 1.76, 95% CI = 1.06, 2.90) among offspring. Maternal anticonvulsant use before or during the index pregnancy was related to CNS tumors in offspring (OR = 1.99, 95% CI = 0.99, 4.00).

调查孕产妇或儿童癫痫、妊娠期使用抗惊厥药和儿童癌症之间关联的研究结果不一致，有时甚至相互矛盾。链接丹麦国家数据库，我们获得了癫痫和儿童癌症诊断以及抗惊厥药使用数据。我们使用条件 logistic 回归估计了与母体或儿童癫痫和抗惊厥治疗相关的所有或特定儿童癌症的调整比值比。母体癫痫与后代的所有儿童癌症呈正相关，特别是急性淋巴细胞白血病 （OR = 1.68,95% 置信区间 （CI） = 1.16,2.43）和肾母细胞瘤 （OR = 2.13,95% CI = 0.97,4.68）。当考虑母体曾经（终生）摄入抗惊厥药时，发现与后代中的所有癌症 （OR = 1.14， 95% CI = 1.00， 1.30） 和中枢神经系统肿瘤 （CNS） （OR = 1.36， 95% CI = 1.04， 1.76） 以及神经母细胞瘤 （OR = 1.76， 95% CI = 1.06， 2.90） 呈正相关。在指数妊娠之前或期间，母体抗惊厥药的使用与后代的 CNS 肿瘤有关 （OR = 1.99,95% CI = 0.99,4.00）。