AimsOur research aims to shed light on the connection between histopathological differences that affect the prognosis of endometrial cancer and Doppler indices measured in the uterine arteries.MethodsSeventy‐four women with a confirmed diagnosis of endometrial cancer participated in this prospective study. The flow characteristics of the bilateral uterine arteries were evaluated and recorded using color Doppler sonography. After hysterectomy, a correlation analysis was performed between these factors and histological findings.ResultsPatients who complained of menometrorrhagia had significantly higher uterine artery peak systolic flow (p = 0.020) than those who had postmenopausal vaginal bleeding. Endometrioid adenocarcinoma was the most common type (71.4%). Doppler pulsatility index and resistance index in the uterine arteries didn't show statistically significant differences between histologic subtypes, tumor grade, myometrial invasion, lymphovascular invasion, lymph node involvement, malignant peritoneal cytology, genetic mutation, or extrauterine involvement. Those without cervical involvement had higher uterine artery Doppler peak systolic flow/end diastolic flow (p = 0.024).ConclusionsEndometrial cancer made uterine artery, myometrium and endometrium less resistant to blood flow. However, these blood flow indices have not been standardized enough to be utilized as diagnostic tests just yet. Standardization based on more advanced studies would make it possible to use ultrasonography for non‐invasive diagnosis and would accelerate and facilitate clinical management.

中文翻译：

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子宫动脉多普勒对子宫内膜癌预后的前瞻性评估：三级单中心经验


目的我们的研究旨在阐明影响子宫内膜癌预后的组织病理学差异与子宫动脉测量的多普勒指数之间的联系。方法74 名确诊为子宫内膜癌的女性参与了这项前瞻性研究。使用彩色多普勒超声检查评估并记录双侧子宫动脉的血流特征。子宫切除术后，对这些因素与组织学结果进行相关分析。结果主诉月经过多的患者的子宫动脉收缩期峰值流量显着高于绝经后阴道出血的患者（p = 0.020）。子宫内膜样腺癌是最常见的类型（71.4%）。子宫动脉多普勒搏动指数和阻力指数在组织学亚型、肿瘤分级、子宫肌层侵犯、淋巴管侵犯、淋巴结受累、恶性腹膜细胞学、基因突变或宫外受累之间没有显示出统计学上的显着差异。无宫颈受累者的子宫动脉多普勒收缩期峰值流量/舒张末期流量较高(p = 0.024)。结论子宫内膜癌使子宫动脉、子宫肌层和子宫内膜对血流的抵抗力降低。然而，这些血流指数尚未标准化到足以用作诊断测试。基于更先进研究的标准化将使使用超声检查进行非侵入性诊断成为可能，并将加速和促进临床管理。