Humankind are being exposed to a cocktail of chemicals, such as chemicals released from plastic food packaging. It is of great importance to evaluate the prevalence of plastic food packaging-derived chemicals pollution along the flow of food-human. We developed a robust and practical database of 2101 chemical features associated with plastic food packaging that combined data from three sources, 925 of which were acquired from non-target screening of chemical extracts from eight commonly used plastic food packaging materials. In this database, 625 features, especially half of the non-targets, were potential migrants who likely entered our bodies through dietary intake. Biomonitoring analysis of plastic chemical features in foodstuffs or human serum samples showed that approximately 78 % of the 2101 features were detectable and approximately half were non-targets. Of these, 17 plastic chemicals with high detection frequencies (DFs) in the human serum were confirmed to be functional chemical additives. Together, our work indicates that the number of plastic chemicals in our bodies could be far greater than previously recognized, and human exposure to plastic chemicals might pose a potential health risk.

中文翻译：

---

追踪从塑料食品包装释放到人类的化学特征


人类正在接触各种化学物质，例如从塑料食品包装中释放的化学物质。评估食品-食品-包装-塑料-食品-包装衍生的化学品污染在食品-人类流动中的普遍性具有重要意义。我们开发了一个强大而实用的数据库，其中包含与塑料食品包装相关的 2101 种化学特征，该数据库结合了来自三个来源的数据，其中 925 个数据是通过对 8 种常用塑料食品包装材料的化学提取物的非靶向筛选获得的。在这个数据库中，625 个特征，尤其是一半的非目标，是可能通过饮食摄入进入我们身体的潜在迁移者。对食品或人类血清样品中塑料化学特征的生物监测分析表明，大约 78% 的 2101 特征是可检测到的，大约一半是非目标特征。其中，17 种人血清中检测频率 （DFs） 高的塑料化学物质被证实为功能性化学添加剂。总之，我们的工作表明，我们体内塑料化学物质的数量可能远超过以前认识到的，人类接触塑料化学物质可能会带来潜在的健康风险。