3D bioprinting technology is widely used in biomedical fields such as tissue regeneration and constructing pathological model. The prevailing printing technique is extrusion-based bioprinting. In this printing method, the bioink needs to meet both printability and functionality, which are often conflicting requirements. Therefore, this study has developed an innovative microvalve-based equipment, incorporating components such as pressure control, a three-dimensional motion platform, and microvalve. Here, we present a droplet-based method for constructing complex three-dimensional structures. By leveraging the rapid switching characteristics of the microvalve, this equipment can achieve precise printing of bio-materials with viscosities as low as 10mPa·s, significantly expanding the biofabrication window for bioinks. This technology is of great significance for 3D bioprinting in tissue engineering and lays a solid foundation for the construction of complex artificial organ tissues.

中文翻译：

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基于微阀控制的3D生物打印技术及设备


3D 生物打印技术广泛应用于组织再生和构建病理模型等生物医学领域。流行的打印技术是基于挤出的生物打印。在这种打印方法中，生物墨水需要同时满足适印性和功能性，这往往是相互冲突的要求。因此，本研究开发了一种创新的基于微阀的设备，其中包含压力控制、三维运动平台和微阀等组件。在这里，我们提出了一种基于液滴的方法，用于构建复杂的三维结构。利用微阀的快速切换特性，该设备可以实现粘度低至 10mPa·s 的生物材料的精确打印，大大扩展了生物墨水的生物制造窗口。该技术对组织工程中的 3D 生物打印具有重要意义，为复杂人工器官组织的构建奠定了坚实的基础。