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ADSCC-CM-Induced Keratin Hydrogel-Based Bioactive Microneedle Patch Containing Triamcinolone Acetonide for the Treatment of Pathological Scar
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2024-09-18 , DOI: 10.1002/adfm.202400457
Cong Li 1, 2 , Bingcheng Yi 3 , Quanchen Xu 1, 4, 5 , Jinlong Ma 1 , Luhan Yuan 1 , Yining Liu 1 , Wei Liu 1 , Ziyi Zhou 1 , Xuchao Ning 1 , Jierui Zhang 1 , Fan Yang 1 , Sisi Wang 1 , Qiang Shi 6 , Qihui Zhou 3, 6 , Zhiguo Wang 1, 2
Affiliation  

Pathological scars (PS) are involved in the excessive response of inflammation and overactivation of myofibroblasts. Herein, a novel microneedle (MN) patch based on the adipose-derived stem cell concentrated conditioned medium (ADSCC-CM) cross-linked keratin hydrogel is developed to load triamcinolone acetonide (TA), thereby achieving the dual-drug delivery of ADSCC-CM and TA to simultaneously reduce the inflammation and guide myofibroblast behaviors. Results not only confirm the ability of ADSCC-CM to drive the formation of keratin-based hydrogel, but also verify the dual-drug release capacities of the hydrogel-developed MNs (TA@AC-MN). Using human hyperplastic scar fibroblast (HSF), the combination of ADSCC-CM and TA demonstrates a pronounced synergistic effect in mitigating the detrimental effects of the inflammatory microenvironment on HSFs, including suppressing the production of reactive oxygen species and attenuating the expression of inflammatory factors. Compared with the clinically used TA, TA@AC-MN promotes scar biomimetic repair (i.e., optimizing the proportion of collagen and increasing the tissue tensile strength). This study demonstrates that TA@AC-MN has the capacity to provide a self-managing and minimally invasive therapeutic strategy for PS.

中文翻译:


ADSCC-CM 诱导的含曲安奈德的基于角蛋白水凝胶的生物活性微针贴剂用于治疗病理性疤痕



病理性疤痕 (PS) 参与炎症的过度反应和肌成纤维细胞的过度激活。在此,开发了一种基于脂肪来源的干细胞浓缩条件培养基 (ADSCC-CM) 交联角蛋白水凝胶的新型微针 (MN) 贴剂来加载曲安奈德 (TA),从而实现 ADSCC-CM 和 TA 的双重药物递送,同时减轻炎症并指导肌成纤维细胞行为。结果不仅证实了 ADSCC-CM 驱动角蛋白基水凝胶形成的能力,还验证了水凝胶开发的 MNs (TA@AC-MN) 的双重药物释放能力。使用人增生性疤痕成纤维细胞 (HSF),ADSCC-CM 和 TA 的组合在减轻炎症微环境对 HSF 的不利影响方面表现出显着的协同作用,包括抑制活性氧的产生和减弱炎症因子的表达。与临床使用的 TA 相比,TA@AC-MN 促进疤痕仿生修复 (即优化胶原蛋白的比例并增加组织拉伸强度)。这项研究表明,TA@AC-MN 有能力为 PS 提供自我管理和微创治疗策略。
更新日期:2024-09-18
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