The Antiphytopathogenic Metabolites and the Synergy of Endophytes Paraphaeosphaeria sp., Nigrospora oryzae from the Same Ginkgo biloba Host,Journal of Agricultural and Food Chemistry

当前位置： X-MOL 学术 › J. Agric. Food Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The Antiphytopathogenic Metabolites and the Synergy of Endophytes Paraphaeosphaeria sp., Nigrospora oryzae from the Same Ginkgo biloba Host
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2024-09-18 , DOI: 10.1021/acs.jafc.4c04237
Fan-Rong Liao ₁ , Wen-Zhi Shi ₁ , Ya-Bin Yang ₁ , Xue-Qiong Yang ₁ , Zhong-Tao Ding _{1,

2}

Affiliation

Two endophytes from the same Ginkgo biloba host were isolated and cultured separately. Three new eremophilane sesquiterpenoids (1–3), three new furan derivates (6, 8–9), one new polyketide (10), and four known compounds (4, 5, 7, 11) from Paraphaeosphaeria sp. and two new 10-membered macrolides (12–13), a new liner polyketide (14), a new benzofuran (15), and six known compounds (16–21) from Nigrospora oryzae were isolated. The structures of the isolated compounds were determined by spectroscopic methods, NMR calculations, and ECD calculations. The compounds 3–7, 9–10, 12, and 14–17 showed significant antiphytopathogenic effects against mycotoxigenic Alternaria sp. comparable to the activity of nystatin (positive control). Compounds 2, 6, 8, 9, and 18 indicated inhibitions against phytopathogen Fusarium asiaticum with MICs < 10 μg/mL. In addition, the compounds with weak antifungal activities from two endophytes were mixed to test their antifungal activity. The results showed that the metabolites from two endophytes had synergistic antifungal effects, and the beneficial interactions between natural products can induce more antifungal effects against plant pathogens than that of single compounds.

中文翻译：

来自同一银杏叶宿主的抗植物病原代谢物和内生菌 Paraphaeosphaeria sp.、Nigrospora oryzae 的协同作用

分离来自同一银杏叶宿主的两种内生菌，分别培养。三种新的嗜倍半萜烯类化合物（1-3），三种新的呋喃衍生物（6， 8-9），一种新的聚酮（10），以及四种已知的化合物（4， 5， 7， 11）来自 Paraphaeosphaeria sp. 和两种新的 10 元大环内酯类（12-13），一种新的衬垫聚酮（14），一种新的苯并呋喃（15）和六种已知化合物（16–21）从 Nigrospora oryzae 中分离出来。分离化合物的结构通过光谱方法、NMR 计算和 ECD 计算确定。化合物 3-7、9-10、12 和 14-17 对产霉毒素链格孢菌属显示出显著的抗植物病原作用，与制霉菌素（阳性对照）的活性相当。化合物 2 、 6 、 8 、 9 和 18 表示对植物病原菌 Fusarium asiaticum 有抑制作用，MICs < 为 10 μg/mL。此外，将来自两种内生菌的抗真菌活性较弱的化合物混合以测试其抗真菌活性。结果表明，两种内生菌的代谢物具有协同抗真菌作用，天然产物之间的有益相互作用比单一化合物更能诱导对植物病原体的抗真菌作用。

更新日期：2024-09-18

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南