From β-Carotene to Retinoids: A Review of Microbial Production of Vitamin A,Journal of Agricultural and Food Chemistry

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From β-Carotene to Retinoids: A Review of Microbial Production of Vitamin A
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2024-09-16 , DOI: 10.1021/acs.jafc.4c06851
Yijun Zhang _{1,

2} , Hongwei Yu _{1,

2} , Lidan Ye _{1,

2}

Affiliation

Vitamin A (retinoids) is crucial for human health, with significant demand across the food, pharmaceutical, and animal feed industries. Currently, the market primarily relies on chemical synthesis and natural extraction methods, which face challenges such as low synthesis efficiency and complex extraction processes. Advances in synthetic biology have enabled vitamin A biosynthesis using microbial cell factories, offering a promising and sustainable solution to meet the increasing market demands. This review introduces the key enzymes involved in the biosynthesis of vitamin A from β-carotene, evaluates achievements in vitamin A production using various microbial hosts, and summarizes strategies for optimizing vitamin A biosynthesis. Additionally, we outline the remaining challenges and propose future directions for the biotechnological production of vitamin A.

中文翻译：

从 β-胡萝卜素到类维生素A：微生物生产维生素 A 的回顾

维生素 A（类维生素A）对人类健康至关重要，食品、制药和动物饲料行业的需求量很大。目前市场主要依赖化学合成和天然提取方法，面临合成效率低、提取工艺复杂等挑战。合成生物学的进步使得利用微生物细胞工厂进行维生素 A 生物合成成为可能，为满足不断增长的市场需求提供了一种有前途且可持续的解决方案。本文介绍了从 β-胡萝卜素生物合成维生素 A 所涉及的关键酶，评估了利用不同微生物宿主生产维生素 A 的成就，并总结了优化维生素 A 生物合成的策略。此外，我们概述了维生素 A 生物技术生产的剩余挑战并提出了未来方向。

更新日期：2024-09-16

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