Conjugated sequence-defined polymers represent a cutting-edge area of polymer science, merging the precision of biological macromolecules with the versatility of synthetic polymers and the unique properties of conjugated systems. While early reports focused on activation/deactivation strategies, this Letter presents the first orthogonal approach to developing sequence-defined conjugated macromolecules (CMs), incorporating a new monomer at each reaction step. In CMs, the primary monomer sequence meticulously determines the optoelectronic properties. Step-by-step, features such as structural defects, chain length, dispersity, functional groups, topology, and monomers used in the backbone are carefully considered and controlled, with optical data provided to support the necessity of sequence-defined approaches in CMs. Additionally, a pioneering and repeatable modular approach is introduced, connecting different orthogonally developed sequences. This method enhances efficiency and accelerates the synthesis process, facilitating comprehensive structure–property analyses and paving the way for tunable materials with record-breaking properties.

中文翻译：

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开发序列定义的共轭大分子的通用策略：实现可调光电特性的有力工具


共轭序列确定的聚合物代表了聚合物科学的前沿领域，将生物大分子的精度与合成聚合物的多功能性和共轭系统的独特特性相结合。虽然早期的报告侧重于活化/失活策略，但本信提出了开发序列定义的共轭大分子 （CM） 的第一种正交方法，在每个反应步骤中加入新的单体。在 CM 中，初级单体序列仔细决定了光电特性。逐步仔细考虑和控制骨架中使用的结构缺陷、链长、分散性、官能团、拓扑和单体等特征，并提供光学数据以支持 CM 中序列定义方法的必要性。此外，还引入了一种开创性的、可重复的模块化方法，连接不同的正交开发序列。这种方法提高了效率并加速了合成过程，促进了全面的结构-性能分析，并为具有破纪录性能的可调材料铺平了道路。