Advancements in food-contaminant detection technologies can significantly improve food safety and human health. Surface-enhanced Raman spectroscopy (SERS) has become the preferred analytical method for food-safety detection owing to its numerous advantages, which include unique ‘molecular fingerprinting’ features, high sensitivity, rapid responses, and non-invasive characteristics. Raman-signal enhancements rely heavily on high-performance SERS substrates. In recent years, metal–organic framework (MOF)-based SERS substrates have gained attention as promising candidates for developing SERS technologies owing to their distinctive structures and functions. This review comprehensively examines recent advances in MOF-based SERS substrates, focusing on the main role of MOFs in SERS substrates as well as their typical categories and structures, construction methods, and representative applications in food-contaminant detection. First, the primary roles of MOFs in SERS substrates are briefly introduced. Next, a comprehensive overview of the typical categories and structures of MOF-based SERS substrates is discussed. Subsequently, a fundamental view of the general construction methods for MOF-based SERS substrates is presented. Next, the main applications of MOF-based SERS substrates for food-contaminant detection are summarised. Finally, challenges and perspectives, including improvements in SERS performance and stability, and the unification of SERS mechanisms, are addressed and discussed.

中文翻译：

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基于 MOF 的 SERS 基质在食品污染物定量分析中的最新进展：综述


食品污染物检测技术的进步可以显着改善食品安全和人类健康。表面增强拉曼光谱（SERS）因其独特的“分子指纹”特征、高灵敏度、快速响应和非侵入性等诸多优点，已成为食品安全检测的首选分析方法。拉曼信号增强在很大程度上依赖于高性能 SERS 基底。近年来，基于金属有机框架（MOF）的SERS基底因其独特的结构和功能而成为开发SERS技术的有希望的候选者而受到关注。该综述全面考察了基于MOF的SERS基底的最新进展，重点介绍了MOF在SERS基底中的主要作用及其典型类别和结构、构建方法以及在食品污染物检测中的代表性应用。首先，简要介绍MOFs在SERS基底中的主要作用。接下来，对基于 MOF 的 SERS 基底的典型类别和结构进行了全面概述。随后，提出了基于 MOF 的 SERS 基底的一般构建方法的基本观点。接下来，总结了基于 MOF 的 SERS 基底在食品污染物检测中的主要应用。最后，讨论和讨论了挑战和前景，包括 SERS 性能和稳定性的改进以及 SERS 机制的统一。