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Unleashing nanotechnology to redefine tumor-associated macrophage dynamics and non-coding RNA crosstalk in breast cancer
Nanoscale ( IF 5.8 ) Pub Date : 2024-09-18 , DOI: 10.1039/d4nr02795g Hardik Patni 1 , Ramesh Chaudhary 1 , Ashutosh Kumar 1
Nanoscale ( IF 5.8 ) Pub Date : 2024-09-18 , DOI: 10.1039/d4nr02795g Hardik Patni 1 , Ramesh Chaudhary 1 , Ashutosh Kumar 1
Affiliation
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Breast cancer is a significant global health issue. Tumor-associated macrophages (TAMs) are crucial in influencing the tumor microenvironment and the progression of the disease. TAMs exhibit remarkable plasticity in adopting distinct phenotypes ranging from pro-inflammatory and anti-tumorigenic (M1-like) to immunosuppressive and tumor-promoting (M2-like). This review elucidates the multifaceted roles of TAMs in driving breast tumor growth, angiogenesis, invasion, and metastatic dissemination. Significantly, it highlights the intricate crosstalk between TAMs and non-coding RNAs (ncRNAs), including microRNAs, long noncoding RNAs, and circular RNAs, as a crucial regulatory mechanism modulating TAM polarization and functional dynamics that present potential therapeutic targets. Nanotechnology-based strategies are explored as a promising approach to reprogramming TAMs toward an anti-tumor phenotype. Various nanoparticle delivery systems have shown potential for modulating TAM polarization and inhibiting tumor-promoting effects. Notably, nanoparticles can deliver ncRNA therapeutics to TAMs, offering unique opportunities to modulate their polarization and activity.
中文翻译：
释放纳米技术重新定义乳腺癌中肿瘤相关巨噬细胞动力学和非编码RNA串扰
乳腺癌是一个重大的全球健康问题。肿瘤相关巨噬细胞（TAM）对于影响肿瘤微环境和疾病进展至关重要。 TAM 在采用不同表型方面表现出显着的可塑性，从促炎和抗肿瘤发生（M1 样）到免疫抑制和肿瘤促进（M2 样）。这篇综述阐明了 TAM 在驱动乳腺肿瘤生长、血管生成、侵袭和转移扩散中的多方面作用。值得注意的是，它强调了 TAM 和非编码 RNA (ncRNA)（包括 microRNA、长非编码 RNA 和环状 RNA）之间复杂的串扰，作为调节 TAM 极化和功能动态的关键调节机制，从而提供了潜在的治疗靶点。基于纳米技术的策略被探索为一种将 TAM 重新编程为抗肿瘤表型的有前途的方法。各种纳米颗粒递送系统已显示出调节 TAM 极化和抑制肿瘤促进作用的潜力。值得注意的是，纳米粒子可以将 ncRNA 疗法传递给 TAM，为调节其极化和活性提供独特的机会。
更新日期：2024-09-18
中文翻译：
释放纳米技术重新定义乳腺癌中肿瘤相关巨噬细胞动力学和非编码RNA串扰
乳腺癌是一个重大的全球健康问题。肿瘤相关巨噬细胞（TAM）对于影响肿瘤微环境和疾病进展至关重要。 TAM 在采用不同表型方面表现出显着的可塑性，从促炎和抗肿瘤发生（M1 样）到免疫抑制和肿瘤促进（M2 样）。这篇综述阐明了 TAM 在驱动乳腺肿瘤生长、血管生成、侵袭和转移扩散中的多方面作用。值得注意的是，它强调了 TAM 和非编码 RNA (ncRNA)（包括 microRNA、长非编码 RNA 和环状 RNA）之间复杂的串扰，作为调节 TAM 极化和功能动态的关键调节机制，从而提供了潜在的治疗靶点。基于纳米技术的策略被探索为一种将 TAM 重新编程为抗肿瘤表型的有前途的方法。各种纳米颗粒递送系统已显示出调节 TAM 极化和抑制肿瘤促进作用的潜力。值得注意的是，纳米粒子可以将 ncRNA 疗法传递给 TAM，为调节其极化和活性提供独特的机会。
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