An Unusual Application of Multifunctional Nanozyme Derived from COF: Augmenting Chemoimmunotherapy while Attenuating Cardiotoxicity,Advanced Functional Materials

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An Unusual Application of Multifunctional Nanozyme Derived from COF: Augmenting Chemoimmunotherapy while Attenuating Cardiotoxicity
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2024-09-17 , DOI: 10.1002/adfm.202412862
Wenxin Lv ₁ , Guangwei Jiang ₂ , Xiaojun Lin ₁ , Min Qian ₂ , Rong Huang ₂ , Zhichao Li ₁ , Hui Liu ₁ , Dan Lin ₁ , Yi Wang ₁

Affiliation

Enhancing therapeutic efficacy while reducing the adverse effects of drugs is crucial in cancer treatments. In this study, nitrogen-doped carbon nanospheres are synthesized with variable enzymatic activities through the pyrolysis of a covalent organic framework (COF). These nanospheres show increased peroxidase (POD) and oxidase (OXD) activities in the tumor microenvironment, generating reactive oxygen species (ROS) that help eliminate tumor cells. Under normal conditions, they display catalase (CAT) and superoxide dismutase (SOD) activities, promoting antioxidative protection. Their porous structure and π–π/hydrophobic interactions allow for the loading of the chemotherapeutic agent doxorubicin (DOX). The nanospheres are then enveloped by tumor cell membranes, stabilizing the drug load and enabling targeted drug delivery with pH-sensitive release. This targeted system induces ferroptosis in tumor cells and activates a strong anti-tumor immune response, leading to enhanced immunotherapy for breast cancer and reduced tumor metastasis to the lungs. Importantly, the varied enzymatic activities of the nanomedicine system help mitigate the cardiotoxicity of DOX chemotherapy, improving cancer treatment while minimizing side effects. This approach introduces a nano-enzyme drug system with distinctive activities and innovative preparation, setting a new standard for efficient, low-toxicity cancer therapy.

中文翻译：

源自 COF 的多功能纳米酶的不寻常应用：增强化学免疫治疗，同时减轻心脏毒性

在癌症治疗中，提高治疗效果并减少药物的不良反应至关重要。在本研究中，通过共价有机框架（COF）的热解合成了具有可变酶活性的氮掺杂碳纳米球。这些纳米球在肿瘤微环境中表现出增加的过氧化物酶（POD）和氧化酶（OXD）活性，产生有助于消除肿瘤细胞的活性氧（ROS）。在正常情况下，它们表现出过氧化氢酶（CAT）和超氧化物歧化酶（SOD）活性，促进抗氧化保护。它们的多孔结构和π-π/疏水相互作用允许化疗药物阿霉素（DOX）的负载。然后，纳米球被肿瘤细胞膜包裹，稳定药物负荷并实现靶向药物递送和 pH 敏感释放。这种靶向系统诱导肿瘤细胞中的铁死亡并激活强大的抗肿瘤免疫反应，从而增强乳腺癌的免疫治疗并减少肿瘤向肺部的转移。重要的是，纳米药物系统的各种酶活性有助于减轻 DOX 化疗的心脏毒性，改善癌症治疗，同时最大限度地减少副作用。这种方法引入了具有独特活性和创新制剂的纳米酶药物系统，为高效、低毒性的癌症治疗树立了新标准。

更新日期：2024-09-17

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