Bacterial infection and tissue damage caused by friction are two major threats to patients’ health in medical catheter implantation. Hydrogels with antibacterial and lubrication effects are competitive candidates for catheter coating materials. Photothermal therapy (PTT) is a highly efficient bactericidal method. Here, a composite hydrogel containing MXene nanosheets and hydrophilic 3-sulfopropyl methacrylate potassium salt (SPMK) is reported, which is synthesized through the one-pot method and heat-initiated polymerization. The hydrogel shows excellent antibacterial performance against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in 3 min in the air or 20 min in the water environment under near-infrared light (NIR; 808 nm) irradiation. The friction coefficient of the hydrogel is about 0.11, which is 48% lower than that without SPMK. The rapid photothermal sterilization is attributed to the outstanding antibacterial ability and thermal effect of photoactivated MXene. The ultra-low friction is the result of the hydration lubrication mechanism. This study provides a potential strategy for the surface coatings of biomedical catheters, which enables rapid sterilization and extremely low interface resistance between catheters and biological tissues.

细菌感染和摩擦引起的组织损伤是医用导管植入过程中对患者健康的两大威胁。具有抗菌和润滑作用的水凝胶是导管涂层材料的有力候选者。光热疗法（PTT）是一种高效的杀菌方法。本文报道了一种含有 MXene 纳米片和亲水性甲基丙烯酸 3-磺基丙酯钾盐 (SPMK) 的复合水凝胶，该水凝胶是通过一锅法和热引发聚合合成的。该水凝胶在近红外光（NIR；808 nm）照射下，在空气中3 min或在水环境中20 min对大肠杆菌（ E. coli ）和金黄色葡萄球菌（ S. aureus ）表现出优异的抗菌性能。水凝胶的摩擦系数约为0.11，比没有SPMK的摩擦系数低48%。快速光热灭菌归功于光活化MXene出色的抗菌能力和热效应。超低摩擦是水合润滑机制的结果。这项研究为生物医学导管的表面涂层提供了一种潜在的策略，可以实现导管与生物组织之间的快速灭菌和极低的界面电阻。