Anterior cruciate ligament (ACL) injuries in sports have become increasingly prevalent, leading to the widespread adoption of polyethylene terephthalate (PET) artificial ligaments for ACL reconstruction due to their superior mechanical properties. However, the bio-inertness of PET presents a significant challenge to graft-bone integration, necessitating the enhancement of PET surface bioactivity. This study employed magnetron sputtering and hydrogel coating techniques to introduce strontium calcium-phosphorus, and magnesium ions onto the surface of PET ligaments, achieving the sequential release of Mg, and Sr ions. The scanning electron microscopy analysis confirmed the uniformity and stability of the modified PET ligament surface material. The synergistic effect of sequential release from Mg/Sr-PET has effectively promoted osteogenesis, angiogenesis, and neuronal differentiation in vitro. Moreover, in the reconstructed ACL model using Sprague-Dawley rats, the histological staining, micro-computed tomography, and biomechanical test results indicated that the Mg/Sr-PET group notably stimulated blood vessel and nerve formation, demonstrating remarkable bone regrowth promotion. In conclusion, the sequential release and synergistic effect of magnesium and strontium ions significantly enhanced graft-bone integration and accelerated rapid healing, offering valuable insights for improving clinical ACL reconstruction outcomes.

中文翻译：

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PET 人工韧带上的磁控溅射双离子顺序释放涂层促进血管神经再生和移植物-骨整合


运动中的前交叉韧带 （ACL） 损伤越来越普遍，由于其卓越的机械性能，导致聚对苯二甲酸乙二醇酯 （PET） 人工韧带被广泛采用用于 ACL 重建。然而，PET 的生物惰性对移植物-骨整合提出了重大挑战，需要增强 PET 表面生物活性。本研究采用磁控溅射和水凝胶涂层技术，将锶、钙磷和镁离子引入 PET 韧带表面，实现 Mg 和 Sr 离子的序列释放。扫描电子显微镜分析证实了改性 PET 韧带表面材料的均匀性和稳定性。Mg/Sr-PET 连续释放的协同作用在体外有效促进了成骨、血管生成和神经元分化。此外，在使用 Sprague-Dawley 大鼠的重建 ACL 模型中，组织学染色、显微计算机断层扫描和生物力学检查结果表明，Mg/Sr-PET 组显着刺激血管和神经形成，表现出显着的骨再生促进。总之，镁和锶离子的序列释放和协同作用显着增强了移植物-骨整合并加速了快速愈合，为改善临床 ACL 重建结果提供了有价值的见解。