Copper-Catalyzed Oxidative α-Double Bond Construction in α-Amino Carbonyl Compounds via Homocoupling with Arylamine Release,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Copper-Catalyzed Oxidative α-Double Bond Construction in α-Amino Carbonyl Compounds via Homocoupling with Arylamine Release
Organic Letters ( IF 4.9 ) Pub Date : 2024-09-17 , DOI: 10.1021/acs.orglett.4c03044
Huan Wang ₁ , Yi-Bin Wang ₁ , Yan-Fang Zhan ₁ , Yi-Ting Zhu ₁ , Yan Jiang ₁ , Sen Yang ₁ , Ming Chen ₁

Affiliation

Herein, we present a copper-catalyzed method for oxidative α-double bond formation in α-amino ketone compounds using DTBP as the oxidant. This process, involving homocoupling of α-amino radicals and arylamine release, efficiently produces a series of enaminone skeletons. The strategy has a broad substrate scope and functional group tolerance. In particular, arylamines bearing electron-rich substituents exhibit a pronounced reactivity. This approach facilitates the synthesis of diverse enaminones, enabling the efficient construction of nitrogen-containing heterocycles.

中文翻译：

铜催化 α-氨基羰基化合物中通过均偶联并释放芳基胺的氧化 α-双键构建

在此，我们提出了一种使用 DTBP 作为氧化剂在 α-氨基酮化合物中氧化形成 α-双键的铜催化方法。该过程涉及 α-氨基自由基的自偶联和芳基胺的释放，有效地产生了一系列烯胺酮骨架。该策略具有广泛的底物范围和官能团耐受性。特别是，带有富电子取代基的芳胺表现出显着的反应性。这种方法有利于多种烯胺酮的合成，从而能够有效构建含氮杂环。

更新日期：2024-09-17

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南