The G396R coding variant in IGHG1, which encodes membrane-bound IgG1 heavy chain, might have arisen within the Southeast Asian population as a potential evolutionary event on an archaic haplotype background. This variant potentiates immune resilience against various life-threatening organisms, illustrating the interplay of human evolution and immune adaptation.

中文翻译：

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B 细胞受体变体赋予针对病原体的进化保护


IGHG1 中的 G396R 编码变体编码膜结合的 IgG1 重链，可能作为古老单倍型背景下的潜在进化事件出现在东南亚人群中。这种变体增强了对各种威胁生命的生物体的免疫弹性，说明了人类进化和免疫适应的相互作用。