We integrated single-cell RNA-sequencing data to provide comprehensive profiles of the cellular composition of the tumor microenvironment and identify their underlying genetic determinants across 23 cancer types. We used this resource to delineate the biological mechanisms by which genetic variants shape the cellular composition of the tumor microenvironment.

中文翻译：

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肿瘤微环境细胞组成的基因组图谱


我们整合了单细胞 RNA 测序数据，以提供肿瘤微环境细胞组成的全面概况，并确定 23 种癌症类型的潜在遗传决定因素。我们利用这一资源来描述遗传变异塑造肿瘤微环境的细胞组成的生物学机制。