Combined art activities can improve the neural network function within various brain regions involved in emotions, cognition, and behavior, thereby preventing or reversing cognitive decline. However, few studies have systematically examined its effects. Furthermore, the impact of nurse-led art-based cognitive intervention on cognitive and psychological health is unclear. To evaluate the effects of a nurse-led staged integral art-based cognitive intervention in older adults on the Alzheimer's disease spectrum. This was a randomized wait-list controlled trial with allocation concealment and blinding of outcome assessors and data analysts. All data were collected between April 2021 and January 2023 and analyzed from January to March 2023. One memory clinic and four medical partnership communities. A total of 144 participants with subjective or objective memory decline (aged ≥60 years). Participants were randomized into an intervention group (n = 72) and a wait-list control group (n = 72), in a 1:1 ratio. The intervention group underwent a 16-week, 24-session nurse-led staged integral art-based cognitive intervention program, which was based on neurocognitive function training patterns. The control group underwent the program after the follow-up assessment. General and specific domains of cognitive function and other health-related outcomes were measured at baseline (T0), immediately after the intervention (T1), and at the 6-month follow-up (T2). Of the 144 participants (mean [SD] age, 71.6 [5.8] years; 50 [34.7 %] males and 94 [65.3 %] females), 130 and 115 completed the questionnaires at T1 and T2, respectively. The average attendance rate in the intervention group was 86.0 %. At T1, the intervention group showed greater improvement than the control group did in general cognitive functions (MoCA, between-group mean difference, 1.4 [95 % CIs, 0.4 to 2.5], p = 0.009). Additionally, the intervention group demonstrated statistically significant improvement compared to the control group in language, memory, quality of life, sleep quality and physical activity level at T1. Statistically significant group differences remained in sleep quality (PSQI, between-group mean difference, −1.3 [95 % CIs, −2.5 to −0.1], p = 0.035) at the 6-month follow-up. In this randomized controlled trial of a nurse-led staged integral art-based cognitive intervention program, older adults on the Alzheimer's disease spectrum who participated in the program experienced improved cognition and psychological health. This study was registered with ChiCTR.org (ChiCTR2100044959) on April 3, 2021. A nurse-led staged integral art-based intervention for older adults on the Alzheimer's disease spectrum experienced improved cognition and psychological health.

中文翻译：

---

护士主导的分阶段综合艺术认知干预对老年人对阿尔茨海默病谱的影响：一项随机对照试验


组合艺术活动可以改善涉及情绪、认知和行为的各个大脑区域的神经网络功能，从而预防或逆转认知能力下降。然而，很少有研究系统地检验其影响。此外，护士主导的基于艺术的认知干预对认知和心理健康的影响尚不清楚。评估护士主导的分阶段整体艺术认知干预对老年人阿尔茨海默氏病的影响。这是一项随机等待名单对照试验，对结果评估者和数据分析师进行分配隐藏和盲法。所有数据均在 2021 年 4 月至 2023 年 1 月期间收集，并在 2023 年 1 月至 3 月期间进行分析。一个记忆诊所和四个医疗合作社区。共有 144 名受试者出现主观或客观记忆衰退（年龄≥60 岁）。参与者按 1:1 的比例随机分为干预组 (n = 72) 和等待名单对照组 (n = 72)。干预组接受了为期 16 周、24 个疗程的护士主导的分阶段整体艺术认知干预计划，该计划以神经认知功能训练模式为基础。对照组在随访评估后接受该计划。在基线 (T0)、干预后立即 (T1) 和 6 个月随访 (T2) 时测量认知功能的一般和特定领域以及其他健康相关结果。在 144 名参与者中（平均 [SD] 年龄为 71.6 [5.8] 岁；50 [34.7 %] 男性和 94 [65.3 %] 女性），分别有 130 人和 115 人在 T1 和 T2 完成了调查问卷。干预组平均出勤率为86.0%。 在 T1 时，干预组在一般认知功能方面比对照组表现出更大的改善（MoCA，组间平均差，1.4 [95% CI，0.4 至 2.5]，p = 0.009）。此外，与对照组相比，干预组在 T1 时的语言、记忆力、生活质量、睡眠质量和体力活动水平方面表现出统计学上显着的改善。在 6 个月的随访中，睡眠质量仍存在统计学上显着的组间差异（PSQI，组间平均差，-1.3 [95% CI，-2.5 至 -0.1]，p = 0.035）。在这项由护士主导的分阶段整体艺术认知干预计划的随机对照试验中，参与该计划的阿尔茨海默病谱系老年人的认知能力和心理健康状况得到改善。这项研究于 2021 年 4 月 3 日在 ChiCTR.org 注册 (ChiCTR2100044959)。一项由护士主导的分阶段基于艺术的针对阿尔茨海默病谱系老年人的综合干预措施改善了认知和心理健康。