An untargeted lipidomic analysis was conducted to investigate the lipid composition of human milk across different lactation stages and gestational ages systematically. A total of 25 lipid subclasses and 934 lipid species as well as 90 free fatty acids were identified. Dynamic changes of the lipids throughout lactation and gestational phases were highlighted. In general, lactation stages introduced more variations in the lipid composition of human milk than gestational ages. Most lipids decreased as the milk progressed from the colostral stage to the mature stage, with some reaching a peak at the transitional stage. Significant variations in lipid composition across gestational ages were predominantly evident during early lactation period. In mature milks, most of the lipids exhibited no discernible statistical differences among gestational ages. This elucidation offers valuable insights and guidance for tailoring precise nutritional strategies for infants with diverse health needs.

中文翻译：

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对不同哺乳期和胎龄的哺乳期妇女的母乳进行全面的脂质组学分析


进行非靶向脂质组学分析，系统研究不同哺乳期和胎龄母乳的脂质组成。共鉴定出 25 个脂质亚类和 934 种脂质以及 90 种游离脂肪酸。强调了脂质在整个哺乳期和妊娠期的动态变化。一般来说，与胎龄相比，哺乳期引入了母乳脂质成分的更多变化。随着乳汁从初乳阶段进入成熟期，大多数脂质下降，有些脂质在过渡期达到峰值。不同胎龄脂质组成的显着差异在哺乳期早期主要很明显。在成熟乳汁中，大多数脂质在胎龄之间没有明显的统计差异。这一阐述为为具有不同健康需求的婴儿量身定制精确的营养策略提供了宝贵的见解和指导。