The behavior of hesperidin methylchalcone (HMC) at the oil/water interface was examined through experimental and molecular simulation methods, and a nano-emulsions based on HMC was subsequently fabricated. The findings indicated that HMC spontaneously aggregated at the oil-water interface, leading to a reduction in interfacial tension and an increase in interfacial thickness. Furthermore, its glycoside and benzene ring showed tendencies to interact with water and medium-chain triglyceride, respectively. The HMC addition amount (w), homogenization times (n) and homogenization pressure (p) significantly influenced the formation of the nano-emulsions. The nano-emulsion with an oil-droplet size of 277.26 ± 13.62 nm was obtained at w = 1.0 %, p = 200 bar, and n = 6. When compared to the Tween 20 nano-emulsion, the HMC nano-emulsion demonstrated superior storage stability, antioxidant activity, and lutein bioaccessibility. It could achieve the slow release of HMC. These findings not only broaden the application range of HMC but also contribute to the advancement of functional nano-emulsions.

中文翻译：

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橙皮苷甲基查尔酮的油/水界面行为及其在纳米乳液中的应用


通过实验和分子模拟方法检查了橙皮苷甲基查尔酮 （HMC） 在油/水界面上的行为，随后制备了基于 HMC 的纳米乳液。结果表明，HMC 在油水界面自发聚集，导致界面张力降低，界面厚度增加。此外，其糖苷和苯环分别表现出与水和中链甘油三酯相互作用的趋势。HMC 添加量 （w）、均质时间 （n） 和均质压力 （p） 显着影响纳米乳液的形成。在 w = 1.0 %、p = 200 bar 和 n = 6 时获得油滴尺寸为 277.26 ± 13.62 nm 的纳米乳液。与 Tween 20 纳米乳剂相比，HMC 纳米乳剂表现出优异的储存稳定性、抗氧化活性和叶黄素的生物可及性。它可以实现 HMC 的慢速发布。这些发现不仅拓宽了 HMC 的应用范围，也有助于功能性纳米乳液的发展。