Despite its many beneficial effects, pharmaceutical applications of curcumin (CUR) are limited due to its chemical instability, low solubility/absorption and weak bioavailability. Recent advances in nanotechnology have enabled the development of CUR-loaded nanodelivery systems to tackle those issues. Within many different nanocarriers developed for CUR up to date, lipid-based nanocarriers (LBNs) are among the most extensively studied systems. LBNs such as nanoemulsions, solid lipid carriers, nanostructured phospholipid/surfactant carriers are shown to be potential delivery systems capable of improving the solubility, bioavailability, and chemical stability of CUR. The particle characteristics, stability, bioavailability, and release properties of CUR-loaded LBNs can be tailored via optimizing the formulation and processing parameters. This paper reviews the most recent studies on the development of various CUR-loaded LBNs. Approaches to the improvement of CUR bioavailability and release characteristics of LBNs are discussed. Furthermore, challenges in the development of CUR-loaded LBNs and their potential applications are presented.

中文翻译：

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姜黄素的脂质纳米递送系统：最新进展、方法和应用


尽管姜黄素 （CUR） 具有许多有益作用，但由于其化学不稳定性、溶解度/吸收率低和生物利用度低，姜黄素 （CUR） 的药物应用受到限制。纳米技术的最新进展使载有 CUR 的纳米递送系统的开发成为可能，以解决这些问题。在迄今为止为 CUR 开发的许多不同的纳米载体中，基于脂质的纳米载体 （LBN） 是研究最广泛的系统之一。LBN 如纳米乳剂、固体脂质载体、纳米结构磷脂/表面活性剂载体被证明是能够提高 CUR 溶解度、生物利用度和化学稳定性的潜在递送系统。CUR 负载的 LBN 的颗粒特性、稳定性、生物利用度和释放特性可以通过优化配方和加工参数来定制。本文回顾了关于各种 CUR 负载 LBN 开发的最新研究。讨论了提高 CUR 生物利用度和 LBN 释放特性的方法。此外，还介绍了 CUR 负载 LBN 开发中的挑战及其潜在应用。