To select an efficient carrier for loading and sustainedly releasing naringin (NAR), complexes of porous starch (PS) and NAR (PS-NAR) as well as those of octenyl succinic anhydride (OSA) esterified PS and NAR (OSAPS-NAR) with different degree of substitution (DS) were prepared by an ultrasonic method with an ethanol solution. The micro-morphological features, structural and thermal properties of complexes and their constituents were characterized, and in vitro release rate and kinetic of NAR from complexes were investigated. The findings revealed that NAR was successfully loaded in PS/OSAPS in an amorphous form, and the NAR's loading efficiency improved as DS increased, reaching 86.85 % at DS 0.0427. NAR cumulative release rate from the complexes in simulated digestion fluids was much higher than that of free (unloaded) NAR, but decreased as DS increased. NAR's in vitro release from complexes mainly depended on the carrier rather than NAR itself, and OSAPS with higher DS had stronger protection and slower release effect on NAR. The results would provide a new means for starch-based carrier construction to develop an efficient delivery and sustainedly releasing system for NAR, thus broadening the application ranges both for modified starch and citrus flavonoids such as NAR.

中文翻译：

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OSA 改性多孔淀粉作为加载和持续释放柚皮苷的有效载体


为了选择一种有效的载体来加载和持续释放柚皮苷 （NAR），采用乙醇溶液的超声方法制备了多孔淀粉 （PS） 和 NAR （PS-NAR） 以及辛烯基琥珀酸酐 （OSA） 酯化 PS 和 NAR （OSAPS-NAR） 的复合物。表征了复合物及其成分的微观形态特征、结构和热特性，并研究了复合物中 NAR 的体外释放速率和动力学。结果表明，NAR 以无定形形式成功加载到 PS/OSAPS 中，并且 NAR 的负载效率随着 DS 的增加而提高，在 DS 0.0427 时达到 86.85 %。模拟消化液中复合物的 NAR 累积释放速率远高于游离（空载）NAR，但随着 DS 的增加而降低。NAR 从复合物中的体外释放主要取决于载体，而不是 NAR 本身，DS 较高的 OSAPS 对 NAR 的保护作用更强，释放作用较慢。结果将为淀粉基载体构建提供一种新的手段，以开发一种高效的 NAR 递送和持续释放系统，从而拓宽了改性淀粉和柑橘类黄酮（如 NAR）的应用范围。