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Non-viral targeted insertion of large payloads into T cells
Nature Biomedical Engineering ( IF 26.8 ) Pub Date : 2024-09-16 , DOI: 10.1038/s41551-024-01252-0
Zsuzsanna Izsvák

The nuclease Cas9 and DNA-repair pathway homology-mediated end joining can be leveraged to efficiently and non-virally integrate large DNA payloads into genomic target sites in primary T cells.

中文翻译:


将大有效负载非病毒靶向插入 T 细胞



可以利用核酸酶 Cas9 和 DNA 修复途径同源介导的末端连接,以有效且非病毒的方式将大量 DNA 有效负载整合到原代 T 细胞的基因组靶位点中。
更新日期:2024-09-16
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