Utilizing solid-state nanopore sensing for high-efficiency and precise targeted localization in antiviral drug development,Analyst

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Utilizing solid-state nanopore sensing for high-efficiency and precise targeted localization in antiviral drug development
Analyst ( IF 3.6 ) Pub Date : 2024-09-16 , DOI: 10.1039/d4an00946k
Wei Xu ₁ , Lichun Zou ₁ , Haiyan Wang ₁ , Changhui Xu ₁ , Qinyang Fan ₁ , Jingjie Sha ₁

Affiliation

The efficient identification and validation of drug targets are paramount in drug discovery and development. Excessive costs, intricate procedures, and laborious sample handling frequently encumber contemporary methodologies. In this study, we introduce an innovative approach for the expeditious screening of drug targets utilizing solid-state nanopores. These nanopores provide a label-free, ultra-sensitive, and high-resolution platform for the real-time detection of biomolecular interactions. By observing the changes in relative ion currents over time after mixing different peptides with small molecule drugs, and supplementing this with noise analysis, we can pinpoint specific regions of drug action, thereby enhancing both the speed and cost-efficiency of drug development. This research offers novel insights into drug discovery, expands current perspectives, and lays the groundwork for formulating effective therapeutic strategies across a spectrum of diseases.

中文翻译：

利用固态纳米孔传感在抗病毒药物开发中实现高效和精确的靶向定位

在药物发现和开发中，药物靶标的高效识别和验证至关重要。过高的成本、复杂的程序和费力的样品处理经常阻碍现代方法。在这项研究中，我们介绍了一种利用固态纳米孔快速筛选药物靶点的创新方法。这些纳米孔为实时检测生物分子相互作用提供了一个无标记、超灵敏和高分辨率的平台。通过观察不同肽与小分子药物混合后相对离子流随时间的变化，并辅以噪声分析，我们可以确定药物作用的特定区域，从而提高药物开发的速度和成本效益。这项研究为药物发现提供了新的见解，扩展了当前的视角，并为在一系列疾病中制定有效的治疗策略奠定了基础。

更新日期：2024-09-16

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