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Cascade Cyclization of N-Cyanamide Alkenes for the Divergent Synthesis of Azido-, Nitro-, and Alkenyl-Containing Pyrroloquinazolinones
Organic Letters ( IF 4.9 ) Pub Date : 2024-09-16 , DOI: 10.1021/acs.orglett.4c02803 Bo Jiang, Cui Zhang, Tai-Gang Fan, Yu-Song Ran, Yun-Tao Shen, Yuan Qu, Ya-Min Li
Organic Letters ( IF 4.9 ) Pub Date : 2024-09-16 , DOI: 10.1021/acs.orglett.4c02803 Bo Jiang, Cui Zhang, Tai-Gang Fan, Yu-Song Ran, Yun-Tao Shen, Yuan Qu, Ya-Min Li
Radical cascade cyclizations of N-cyanamide alkenes have been developed for the divergent synthesis of pyrroloquinazolinones bearing azido, alkenyl, and nitro groups by controlling the reaction conditions. The reaction temperature and the loading of the base play important roles in the different reaction pathways. These reactions are characterized by wide functional group compatibility and mild conditions.
中文翻译:
N-氰酰胺烯烃的级联环化用于含叠氮基、硝基和烯基的吡咯并喹唑啉酮的不同合成
N-氰酰胺烯烃的自由基级联环化已被开发用于通过控制反应条件来不同合成带有叠氮基、烯基和硝基的吡咯并喹唑啉酮。反应温度和碱的负载量在不同的反应途径中起着重要作用。这些反应具有官能团相容性广、条件温和的特点。
更新日期:2024-09-16
中文翻译:
N-氰酰胺烯烃的级联环化用于含叠氮基、硝基和烯基的吡咯并喹唑啉酮的不同合成
N-氰酰胺烯烃的自由基级联环化已被开发用于通过控制反应条件来不同合成带有叠氮基、烯基和硝基的吡咯并喹唑啉酮。反应温度和碱的负载量在不同的反应途径中起着重要作用。这些反应具有官能团相容性广、条件温和的特点。