Pyridines and cyclopropanes are important structural units in chemistry. Herein, we introduce a photoredox-catalyzed approach for the ring opening and 1,3-oxypyridylation of aryl cyclopropanes using 4-cyanopyridines and carboxylic acids. This sequential process involves single-electron oxidation of the aryl cyclopropane, leading to nucleophilic ring opening and radical pyridylation at the benzylic position. The redox-neutral reaction exhibits high regioselectivity under mild reaction conditions, offering a broad substrate scope and wide applicability.

中文翻译：

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芳基环丙烷的光催化区域选择性氧化还原中性 1,3-氧化吡啶化


吡啶和环丙烷是化学中重要的结构单元。在此，我们介绍了一种使用 4-氰基吡啶和羧酸进行芳基环丙烷开环和 1,3-氧基吡啶化的光氧化还原催化方法。该连续过程涉及芳基环丙烷的单电子氧化，导致亲核开环和在苄基位置上的自由基吡啶化。氧化还原中性反应在温和的反应条件下表现出较高的区域选择性，提供了广泛的底物范围和广泛的适用性。