We developed an organophotoredox catalytic system to facilitate the decarboxylative allylation coupling process concerning α-amino acids and related C-terminal carboxylate peptides using Morita–Baylis–Hillman adducts as allylic precursors. This metal-free method operates under mild conditions and is compatible with various amino acids. The versatility of this protocol, particularly in chemical biology research, has been preliminarily demonstrated through the ligation of bioactive peptide chains.

中文翻译：

---

无金属条件下 α-氨基酸和肽的光催化脱羧烯丙基化


我们开发了一种有机光氧化还原催化系统，以使用 Morita-Baylis-Hillman 加合物作为烯丙基前体，促进 α-氨基酸和相关 C 末端羧酸肽的脱羧烯丙基化偶联过程。这种无金属方法操作条件温和，并且与各种氨基酸相容。该协议的多功能性，特别是在化学生物学研究中，已通过生物活性肽链的连接得到初步证明。