We report a mild method for the copper-catalyzed amination of aryl chlorides. Key to the success of the method was the use of highly sterically encumbered N¹,N²-diaryl diamine ligands which resist catalyst deactivation, allowing reactions to proceed at significantly lower temperatures and with a broader scope than current protocols. A sequence of highly chemoselective C–N and C–O cross-coupling reactions were demonstrated, and mechanistic studies indicate that oxidative addition of the Cu catalyst to the aryl chlorides is rate-limiting. We anticipate that the design principles disclosed herein will help motivate further advances in Cu-catalyzed transformations of aryl chlorides.

中文翻译：

---

在温和反应条件下铜催化芳基氯化物胺化反应


我们报道了一种用于铜催化芳基氯化物胺化反应的温和方法。该方法成功的关键是使用高度空间位阻的 N^{1，N 2}-二芳基二胺配体，这些配体可抵抗催化剂失活，允许反应在明显较低的温度下进行，并且范围比当前方案更广。证明了一系列高化学选择性的 C-N 和 C-O 交叉偶联反应，机理研究表明 Cu 催化剂与芳基氯化物的氧化加成是限速的。我们预计本文披露的设计原则将有助于推动 Cu 催化芳基氯化物转化的进一步进展。