A dearomative functionalization approach of abundant N-heteroarenes has been developed to harvest valued 3D N-heterocyclic skeletons. This robust method is enabled by the in situ generation of highly reactive non-symmetric iodane from bench-stable hypervalent iodane, PhI(OAc)₂, and BF₃ ⋅ OEt₂ A wide range of N-heteroarenes were transformed into their corresponding 3D analog via the installation of a highly versatile cyano group as a new vector.

中文翻译：

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一种通过平面 N-杂芳烃的 1,2-二氰化获得 3D 杂环的模块化方法


已经开发了一种丰富的 N-杂芳烃的去浪漫功能化方法来收获有价值的 3D N-杂环骨架。这种稳健的方法是通过从台式稳定的高价碘 PhI（OAc）₂ 和 BF₃ ⋅ OEt₂ 原位生成高反应性非对称碘来实现的。通过安装高度通用的氰基作为新载体，将各种 N-杂芳烃转化为相应的 3D 类似物。