Joint Association of Combined Healthy Lifestyle Factors and Hearing Loss with Cognitive Impairment in China,The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

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Joint Association of Combined Healthy Lifestyle Factors and Hearing Loss with Cognitive Impairment in China
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences ( IF 4.3 ) Pub Date : 2024-09-14 , DOI: 10.1093/gerona/glae226
Feifan Zhao _{1,

2} , Zhentao Wang _{1,

2} , Zaichao Wu _{1,

2} , Xueling Wang _{1,

2} , Yun Li _{1,

2} , Yunge Gao _{1,

2} , Kun Han _{1,

2} , Qiongfei Yu _{1,

2} , Cai Wu _{1,

2} , Jie Chen _{1,

2} , Dan Zhao ₃ , Keqing Dong ₄ , Yan Qian ₅ , Xuanyi Wu ₆ , Ying Chen _{1,

2} , Hao Wu _{1,

2}

Affiliation

Background Hearing loss and lifestyle factors have been associated with cognitive impairment. We aimed to explore the joint association of combined healthy lifestyle factors and hearing loss with cognitive impairment, which has been scarcely studied. Methods This baseline study used data from the CHOICE-Cohort study (Chinese Hearing Solution for Improvement of Cognition in Elders). Hearing loss was assessed by the better-ear pure-tone average (BPTA). A composite healthy lifestyle score was built based on never smoking, never drinking, regular physical activity, and balanced diet. Cognitive impairment was diagnosed by the Mini-Mental State Examination (MMSE) score of less than 24. Results We included 17057 participants aged 60 years or older in China (mean age 69.8 [SD 6.2] years, 55.7% female). Among the participants, 48.3% (n=8234) had mild hearing loss, and 25.8% (n=4395) had moderate or greater hearing loss. The proportion of participants with healthy lifestyle scores of 0-1, 2, 3, and 4 was 14.9% (n=2539), 29.3% (n=5000), 37.4% (n=6386), and 18.4% (n=3132), respectively. 29.6% (n=5057) participants had cognitive impairment. When compared to those with normal hearing and healthy lifestyle (scores of 3-4), participants with hearing loss plus unhealthy lifestyle (scores of 0-2) exhibited approximately twofold increased risk of cognitive impairment (OR=1.92, 95% CI 1.70-2.18). Conversely, the risk was greatly attenuated by adherence to healthy lifestyle in individuals with hearing loss (OR=1.57, 95% CI 1.40-1.76). Conclusions Our findings demonstrated adherence to a broad range of healthy lifestyle factors was associated with a significantly lower risk of cognitive impairment among participants with hearing loss.

更新日期：2024-09-14

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