Background Few studies have explored the association between stair climbing and osteoarthritis (OA) to determine whether the former is a protective or risk factor for the latter. This study prospectively evaluated the associations among stair climbing, genetic susceptibility, and their interaction with the risk of incident hip/knee OA. Methods The cohort analyses included 398,939 participants from the UK Biobank. Stair climbing was assessed using a questionnaire. Genetic risk scores (GRSs) consisting of 70, 83, and 87 single-nucleotide polymorphisms for hip, knee, and hip/knee OA were constructed. Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations among stair climbing, genetic predisposition, and hip and/or knee OA risk. Results After 3,621,735 person-years of follow-up, 31,940 patients developed OA. Stair climbing was positively associated with incident hip/knee (P for trend<0.001) and knee (P for trend<0.0001) OA but not hip OA. After adjustments, compared with no stair climbing, climbing >150 steps/day was associated with a higher risk of hip/knee OA (HR, 1.08; 95% CI, 1.03–1.12) and knee OA (HR, 1.13; 95% CI, 1.06–1.20). Although no significant interaction between stair climbing and the GRS of OA risk was found, the above associations were only significant in participants with middle and high GRSs. Conclusion A higher frequency of stair climbing was positively associated with the risk of knee OA but not hip OA, highlighting the importance of avoiding frequent stair climbing in preventing knee OA, especially in genetically predisposed individuals.

中文翻译：

---

爬楼梯、遗传倾向和髋/膝骨关节炎的风险


背景 很少有研究探讨爬楼梯与骨关节炎 (OA) 之间的关联，以确定前者是后者的保护因素还是危险因素。这项研究前瞻性地评估了爬楼梯、遗传易感性之间的关联，以及它们与髋/膝关节骨关节炎发生风险的相互作用。方法 队列分析包括来自英国生物银行的 398,939 名参与者。使用问卷评估爬楼梯。构建了由髋部、膝部和髋部/膝部 OA 的 70、83 和 87 个单核苷酸多态性组成的遗传风险评分 (GRS)。 Cox 比例风险回归模型用于估计爬楼梯、遗传易感性和髋部和/或膝部 OA 风险之间关联的风险比 (HR) 和 95% 置信区间 (CI)。结果 经过 3,621,735 人年的随访，31,940 名患者出现 OA。爬楼梯与髋/膝关节骨关节炎（P 为趋势<0.001）和膝关节骨关节炎（P 为趋势<0.0001）呈正相关，但与髋关节骨关节炎无关。调整后，与不爬楼梯相比，每天爬 >150 步与髋部/膝部 OA（HR，1.08；95% CI，1.03–1.12）和膝部 OA（HR，1.13；95% CI）的较高风险相关。 ，1.06–1.20）。尽管没有发现爬楼梯与 OA 风险 GRS 之间存在显着的交互作用，但上述关联仅在 GRS 中和高的参与者中才显着。结论 较高的爬楼梯频率与膝关节 OA 的风险呈正相关，但与髋关节 OA 的风险无关，这凸显了避免频繁爬楼梯对于预防膝关节 OA 的重要性，特别是对于有遗传倾向的个体。