Is intravenous infusion an unrecognized route for internal microplastic human exposure? A general assessment,Journal of Hazardous Materials

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Is intravenous infusion an unrecognized route for internal microplastic human exposure? A general assessment
Journal of Hazardous Materials ( IF 12.2 ) Pub Date : 2024-09-14 , DOI: 10.1016/j.jhazmat.2024.135769
Tiefeng Cui ₁ , Kai Liu ₁ , Lixin Zhu ₁ , Xiaohui Wang ₁ , Xuri Dong ₁ , Khalida Jabeen ₁ , Changxing Zong ₁ , Xinghuo Wang ₁ , Nian Wei ₁ , Yinan He ₁ , Qingqing Li ₁ , Meng Jiao ₁ , Jungang Lu ₁ , Xinyu Bu ₁ , Daoji Li ₁

Affiliation

As newly recognized environmental pollutants, microplastics (MPs, ≤5 mm in length) have been reported in various human tissues and fluids, including the spleen, liver, heart, blood and blood clots, raising global concerns about their impact on human health. This study investigated the characteristics of MPs in intravenous infusion and the removal of MPs from infusion products by infusion sets fitted with different filters using micro-Fourier Transform Infrared Spectroscopy. MPs were detected in infusion products, with an average abundance of 1.24 ± 1.44 items/unit (2.91 ± 3.91 items/L). The primary types of MPs identified were fragmented particles of polyethene and polypropylene, ranging in size from 15–100 µm. Internal filters in infusion sets played a crucial role in removing MPs, particularly fibrous ones, resulting in a reduction in both abundance and particle size of MPs in the human body. Moreover, this study conducted a general assessment of intravenous microplastic exposure among hospital patients and estimated the global per-person input of MPs via intravenous administration. It is an opportunity for us to gain a deeper understanding of MPs in intravenous infusion and provides guides selecting infusion devices, increasing awareness of associated health risks.

中文翻译：

静脉输注是人类内部微塑料暴露的未公认的途径吗？一般评估

据报道，作为新发现的环境污染物，微塑料（MP，≤5 毫米长）存在于各种人体组织和体液中，包括脾脏、肝脏、心脏、血液和血栓，引起了全球对其对人类健康影响的关注。本研究使用微傅里叶变换红外光谱调查了静脉输注中 MP 的特性以及通过装有不同过滤器的输液器从输液产物中去除 MP。在输液产品中检测到 MP，平均丰度为 1.24 ± 1.44 项/单位（2.91 ± 3.91 项/升）。鉴定出的主要 MP 类型是聚乙烯和聚丙烯的碎片颗粒，大小从 15 微米到 100 微米不等。输液器中的内部过滤器在去除 MP，尤其是纤维 MP 方面起着至关重要的作用，导致人体内 MP 的丰度和粒径减小。此外，本研究对医院患者静脉注射微塑料暴露进行了一般评估，并估计了通过静脉给药的 MP 的全球人均输入。这是我们更深入地了解静脉输液中的 MP 的机会，并提供选择输液装置的指南，提高对相关健康风险的认识。

更新日期：2024-09-14

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