Interlocking G-Quadruplexes Using a G-Triad•G Connection: Implications for G-Wire Assembly,Journal of the American Chemical Society

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Interlocking G-Quadruplexes Using a G-Triad•G Connection: Implications for G-Wire Assembly
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2024-09-14 , DOI: 10.1021/jacs.4c05713
Abhishek Singh ₁ , Fernaldo Richtia Winnerdy ₁ , Constanza Avendaño Avila ₂ , Claude Nogues ₂ , Anh Tuân Phan _{1,

3} , Brahim Heddi ₂

Affiliation

G-quadruplexes are noncanonical structures of nucleic acids formed mainly by G-rich sequences and play crucial roles in important cellular processes. They are also increasingly used in nanotechnology for their valuable properties. Various unexpected structures of G-quadruplexes have been solved recently, including a stable G-quadruplex lacking one guanine in the G-tetrad core, harboring a vacant site. In this study, we demonstrate the interlocking of two intramolecular G-quadruplexes: one containing a vacant site (4n – 1) and the other with an unbound guanine (4n + 1). These G-quadruplexes interact through a G-triad-G connection with unprecedented 5′–3′ stacking. Using these interconnection properties, we have identified a sequence capable of self-assembling into G-wires in K⁺ solutions with potential nanotechnological applications.

中文翻译：

使用 G-Triad•G 连接互锁 G-四联体：对 G 线组装的影响

G-四链体是主要由富含G的序列形成的核酸的非规范结构，在重要的细胞过程中发挥着至关重要的作用。由于其宝贵的特性，它们也越来越多地用于纳米技术。最近，各种意想不到的 G-四联体结构已得到解决，包括稳定的 G-四联体，其 G-四联体核心中缺少一个鸟嘌呤，并存在一个空位。在这项研究中，我们证明了两个分子内 G 四链体的连锁：一个包含空位 (4 n – 1)，另一个包含未结合的鸟嘌呤 (4 n + 1)。这些 G-四联体通过 G-三联体-G 连接以前所未有的 5'–3' 堆叠相互作用。利用这些互连特性，我们已经确定了能够在 K ⁺溶液中自组装成 G 线的序列，具有潜在的纳米技术应用。

更新日期：2024-09-14

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