Red Blood Cell-Derived Small Extracellular Vesicles Inhibit Influenza Virus through Surface-Displayed Sialic Acids,Angewandte Chemie International Edition

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Red Blood Cell-Derived Small Extracellular Vesicles Inhibit Influenza Virus through Surface-Displayed Sialic Acids
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-09-14 , DOI: 10.1002/anie.202413946
Niangui Cai ₁ , Xiaozhen Zhan ₁ , Qingyuan Zhang ₁ , Haonan Di ₁ , Chen Chen ₁ , Yunyun Hu ₁ , Xiaomei Yan ₂

Affiliation

Red blood cell-derived small extracellular vesicles (RBC sEVs) inhibit influenza virus infection by binding to the viral hemagglutinin (HA) via surface-displayed sialic acids (SAs). Acting as nanodecoys, RBC sEVs prevent viral attachment to host cells, effectively blocking infection. Removal of SAs from RBC sEVs significantly reduces their antiviral efficacy, highlighting the importance of SA-HA binding.

中文翻译：

红细胞来源的小细胞外小囊泡通过表面显示的唾液酸抑制流感病毒

红细胞来源的小细胞外囊泡（RBC sEV）通过表面显示的唾液酸（SA）与病毒血凝素（HA）结合来抑制流感病毒感染。作为纳米诱饵，RBC sEV 可防止病毒附着在宿主细胞上，有效阻断感染。从 RBC sEV 中去除 SAs 会显著降低其抗病毒功效，突出了 SA-HA 结合的重要性。

更新日期：2024-09-14

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