Non-Natural MUC1 Glycopeptide Homogeneous Cancer Vaccine with Enhanced Immunogenicity and Therapeutic Activity,Angewandte Chemie International Edition

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Non-Natural MUC1 Glycopeptide Homogeneous Cancer Vaccine with Enhanced Immunogenicity and Therapeutic Activity
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-09-14 , DOI: 10.1002/anie.202411009
Ana Guerreiro ₁ , Ismael Compañón ₂ , Foivos S Lazaris ₂ , Carlos Labão-Almeida ₁ , Paula Oroz ₂ , Mattia Ghirardello ₂ , Marta C Marques ₁ , Francisco Corzana ₂ , Gonçalo J L Bernardes ₃

Affiliation

A chemically defined vaccine is prepared by combining the structural design of a non-natural glycopeptide antigen with a site-specific protein modification. The resulting vaccine, which contains a single copy of the antigen, is both prophylactically and therapeutically effective. Importantly, this approach refutes a prevailing dogma that glycoconjugate vaccines require multivalent presentation of antigens.

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