Biocatalytic Desymmetrization for the Atroposelective Synthesis of Axially Chiral Biaryls Using an Engineered Imine Reductase,Angewandte Chemie International Edition

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Biocatalytic Desymmetrization for the Atroposelective Synthesis of Axially Chiral Biaryls Using an Engineered Imine Reductase
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-09-13 , DOI: 10.1002/anie.202416569
Pengpeng Zhang ₁ , Bo Yuan ₁ , Junkuan Li ₁ , Congcong Li ₁ , Jiaxin Guo ₁ , Bowen Zhang ₁ , Ge Qu ₁ , Hao Su ₁ , Nicholas J Turner ₂ , Zhoutong Sun ₃

Affiliation

Two imine reductases were identified and engineered to construct axially chiral biaryl amines via desymmetrization. The methodology was applied to 24 structurally diverse substrates with high efficiency and atroposelectivity. Molecular dynamics simulation on the variants reveals the mechanisms for increased activity and atroposelectivity. This strategy enriches the toolbox for the biocatalytic synthesis of atropisomers.

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